CD177 ⁺ neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration (Yan J, Huang A, Zhang S, Yao N, Huang J, Jiang Z, Wang J, Chen F, Yu Q, Cheng J, Zhang S, Li T, Gao R, Miao R, Luo R, Zhou S, Ji Y, Wang Z, Gao D, Ding Z, Tang Z, Fan J, Esteban MA, Schlitt HJ, Yang X, Zhou J. CD177⁺neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration. Gut. 2025 Dec 13:gutjnl-2025-336300. doi: 10.1136/gutjnl-2025-336300. Epub ahead of print. PMID: 41390175.)

研究结果显示CD177中性粒细胞通过促进内皮迁移、ECM降解和HGF-α释放来驱动肝脏再生。这些发现揭示了一种中性粒细胞介导的手术肝脏再生机制，并支持CD177中性粒细胞输注在肝功能衰竭治疗策略中建立促进再生肝脏环境的潜力。