相册共1张
点击图片可以查看相册
Mouse Fc Receptor Binding Inhibitor Antibody
- 类型:流式抗体
- 品牌:PBM
- 种属:Mouse应用:Flow,IHC,Functional,Neu/中和实验,Block/阻断反应,IHC(P),IHC(F),抑制试剂 (IA)抗体亚型:IgG2a Lamda宿主:Rat克隆号:93浓度:0.5 mg/mL
规格: 100μg
货号: AM1016010
价格: ¥1018.00
规格: 200μg
货号: AM1016020
价格: ¥2036.00
规格: 1000μg
货号: AM1016100
价格: ¥4224.00
应用 |
建议稀释比 |
|
免疫组化 (IHC) |
- |
|
免疫组化(石蜡) (IHC (P)) |
- |
|
免疫组化(冰冻) (IHC (F)) |
- |
|
中和实验 (Neu) |
- |
|
流式细胞分析 (Flow) |
0.5 µg/test |
|
功能检测 (Functional) |
- |
|
抑制试剂 (IA) |
- |
|
阻断反应 (BLOCK) |
- |
|
产品详细信息
Description: The 93 monoclonal antibody reacts with an epitope shared by mouse CD16 and CD32. CD16 (Fc gamma III Receptor) and CD32 (Fc gamma II Receptor) are the low affinity receptors for the mouse IgG Fc portion and are expressed by B cells, monocyte/macrophages, NK cells, and neutrophils.
靶标信息
CD16 is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by natural killer (NK) cells, and some T cells and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC (antibody dependent cell mediated cytotoxicity) by NK cells. IN comparison, CD32 is a 40 kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII), and mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets. Further, CD32 is involved in the phagocytosis of immune complexes, the regulation of antibody production by B-cells, and variations of the CD32 gene may increase vulnerability to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms of CD32 have been found.
|