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Human Fc Receptor Binding Inhibitor Polyclonal Antibody
- 类型:流式抗体
- 品牌:PBM
- 种属:Human应用:Flow,ICC/IF,Functional,抑制试剂 (IA)浓度:1 mg/mL
规格: 25T
货号: AH1016025
价格: ¥869.00
规格: 100T
货号: AH1016010
价格: ¥1503.00
应用 |
建议稀释比 |
|
免疫细胞化学 (ICC/IF) |
- |
|
功能检测 (Functional) |
- |
|
流式细胞分析 (Flow) |
20 µL/test |
|
抑制试剂 (IA) |
- |
|
产品详细信息
Description: The human FcgammaR-binding inhibitor can be used to inhibit the non-specific Fc-gamma receptor (FcgammaR)-mediated binding of mouse monoclonal antibodies used for flow cytometric analysis of human tissue. Four different classes of Fcgamma receptors have been identified: FcgammaRI (CD64), FcgammaRII (CD32), and FcgammaRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcgammaR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcgammaR varies depending on the isotype of the monoclonal antibody. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcgammaRs.
靶标信息
Four different classes of Fcy receptors have been identified: FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcyR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcyR varies depending on the isotype of the monoclonal antibody. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcyRs.
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