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Recombinant Human IL-12 p70 (CHO derived)
- 类型：细胞因子及添加物
- 品牌：PeproTech
- 种属：Human应用：WB,ELISA,Functional
规格: 2μg
货号: 200-12-2
价格: ¥1195.00
规格: 10μg
货号: 200-12-10
价格: ¥2913.00
规格: 50μg
货号: 200-12-50
价格: ¥13629.00
规格: 100μg
货号: 200-12-100
价格: ¥23138.00
规格: 250μg
货号: 200-12-250
价格: ¥39762.00
规格: 500μg
货号: 200-12-500
价格: ¥59075.00
规格: 1mg
货号: 200-12-1000
价格: ¥90159.00
数量:
产品规格 |
|
种属 |
Human |
已发表种属 |
Bacteria, Hamster, Human, Mouse, Rat |
Expression System |
CHO cells |
氨基酸序列 |
p35 subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS |
分子量 |
75 kDa |
分类 |
Recombinant |
类型 |
Protein |
纯度 |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
内毒素浓度 |
<1 EU/µg |
活性 |
Assay 1: Determined by its ability to induce IFN-gamma production from NK cells co-stimulated with IL-18. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg. Assay 2: Determined by its ability to increase IFN-gamma production by anti-TCR mAb-stimulated PBMCs. The expected ED50 for this effect is 4.0-8.0 ng/ml. |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
纯化类型 |
purified |
内含物 |
no preservative |
保存条件 |
-20°C |
运输条件 |
Ambient |
产品详细信息
200-12-1MG will be provided as 2 x 500 µg (200-12-500UG).
Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.
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